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Additional info for Biosynthesis and Secretion of Milk / Diseases
However, caution must be exerted in the intepretation of the low acetyl-CoA carboxylase activities because of the difficulties encountered in assaying this enzyme. The in vitro assay requires activation of acetylCoA carboxylase to the polymeric form for maximum activity. The regulatory role postulated for acetyl-CoA carboxylase in mammary fatty acid synthesis is supported by the changes which occur in the activity of this enzyme at the initiation of lactation and at involution. 97 between acetyl-CoA carboxylase activity and lipogenic capacity of the tissue as measured by in vitro incubations ( Mellenberger et al, 1973 ).
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