By Rodney J. Y. Ho
Biotechnology and Biopharmaceuticals: remodeling Proteins and Genes into medicinal drugs, moment Edition addresses the pivotal matters in terms of translational technological know-how, together with preclinical and scientific drug improvement, regulatory technological know-how, pharmaco-economics and cost-effectiveness concerns. the hot variation additionally offers an replace on new proteins and genetic medicinal drugs, the translational and built-in sciences that proceed to gas the recommendations in drugs, in addition to the recent components of healing improvement together with melanoma vaccines, stem mobilephone therapeutics, and cell-based remedies.
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Whereas the genomic revolution has fast ended in the deposit of greater than 30,000 buildings within the protein information financial institution (PDB), under one percentage of these contributions characterize membrane proteins although membrane proteins represent a few 20 percentage of all proteins. This discrepancy turns into considerably not easy while it really is coupled with the truth that 60 percentage of present medications are in line with concentrating on this workforce of proteins, a development that doesn't appear more likely to opposite.
With contribution by means of a number of specialists
Biotechnology and Biopharmaceuticals: reworking Proteins and Genes into medicines, moment version addresses the pivotal concerns with regards to translational technology, together with preclinical and medical drug improvement, regulatory technological know-how, pharmaco-economics and cost-effectiveness concerns. the hot variation additionally presents an replace on new proteins and genetic drugs, the translational and built-in sciences that proceed to gas the techniques in drugs, in addition to the hot parts of healing improvement together with melanoma vaccines, stem phone therapeutics, and cell-based cures.
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Extra resources for Biotechnology and biopharmaceuticals : transforming proteins and genes into drugs
A broad definition of biotechnology includes beer and wine fermentation technology to produce distinctive beverages with commercial advantages, the identification of non-virulent variants to use as vaccines, genetic manipulation to coax bacteria to express metabolic enzymes that transform petroleum products into water-soluble forms for environmental clean-up, and the development of a recombinant, disease-resistant fruit or vegetable crop with prolonged freshness. Very often, biotechnology means commercialization of biological and life sciences by integrating discoveries from many disciplines, including microbiology, biochemistry, genetics, chemical biology, and bioengineering.
Of these, only about 10% actually make it through clinical trials and become approved for marketing (Borchardt 2001). With the increasing cost of drug development, this low success rate is even more challenging for infections that affect a few hundred individuals in developing countries. Pharmaceutical companies cannot justify the overall cost of developing drugs for these so-called neglected diseases. A number of strategies are used by established, start-up, or nonprofit organizations to improve efficiency and accelerate product development.
While biotechnology today is seen as the cutting edge of life sciences, the use of biological molecules as therapeutic agents or biologics has existed since the 1800 s. In fact, the word biotechnology can be traced back to the 1919 writing of Kark Erely in his 84-page publication entitled, “Biotechnologie der Fleisch-, Fett- und Milcherzeugung im landwirtschafttichen Gross-betrieb” (Bud 1989). The coining of the term biotechnologie or “biotechnology” by Erely was likely intended to describe the interaction of biology with technology, thus essentially implying inclusion of all biological and related technologies in product transformation.