Brain damage and repair : from molecular research to by T. Herdegen, J. Delgado-Garcia

By T. Herdegen, J. Delgado-Garcia

This publication builds a unique bridge from molecular study to medical treatment. This technique unearths the practical beneficial properties of neurons and glia within the specific context of vulnerability and self-protection, intracellular homes and extracellular matrix. coming up from this platform, this quantity unfolds the molecular and systemic techniques underlying migration problems, axonal harm, fix and regeneration.

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Alvarez, J. & Koenig, E. (2002). Axonal and presynaptic protein synthesis: new insights into the biology of the neuron. Trends in Neurosciences 25: 400-404. P. (1996). Target dependence of motoneurones. In: The neurobiology of disease: contributions from neuroscience to clinical neurology (Ed. H. Bostock, P. Kirkwood & A. Pullen), pp 379-394. Cambridge: Cambridge University Press. Mazzarello, P. (1999). A unifying concept: the history of cell theory. Nature Cell Biology 1: 13-15. B. (1967). Enzyme localisation and ultrastructure of neurons.

One more from the long list of examples of the prominent functional significance of differential splicing can be provided by two forms of FosB protein that may associate with Jun proteins to form AP-1 transcription factor (see above). The isoform known as ∆FosB, with truncated Cterminus, is much more stable than the full length FosB, and it has been suggested to play an important regulatory role in a process of addiction, because it was found to be accumulated in specific brain structures in response to treatment with drugs of abuse.

Among the fastest to be turned-over are products of IEGs. Defined mRNA sequences are responsible for this rapid degradation. Recent discovery of micro RNA and small interfering (si) RNA points also to an involvement of these molecules in downregulating specific mRNA species. Another interesting way of mRNA regulation is provided by means of editing. mRNA editing is a process occurring in the cytoplasm and allowing for a specific change in the mRNA sequence by replacing one nucleotide with another.

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