Cardiovascular and Cardiac Therapeutic Devices by Thomas Franz

By Thomas Franz

This quantity makes a speciality of most up-to-date study in healing units for cardiovascular, i.e. vascular and valvular and cardiac ailments. within the sector of vascular cures, elements coated relate to most modern examine in small-diameter tissue-regenerative vascular grafts, one of many maximum persisting demanding situations in cardiovascular remedies, stent grafts and endovascular stents for percutaneous arterial interventions. Contributions on valvular cures specialise in tissue engineered and tissue regenerative prosthetic middle valves and valvular prostheses for trans-apical implantation together with the demanding situations posed at the prosthesis layout. The part on cardiac illnesses goals at protecting healing advances for myocardial infarction and prevention of middle failure and on in vivo biomechanics of implantable cardiac pacemaker units. a different part enhances those 3 parts by way of providing constitutive modelling of sentimental organic tissues of the cardiovascular procedure, a space central for complex numerical and computational modelling within the improvement and optimisation of cardiovascular units and therapies.

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Eng. 40(9), 1961–1970 (2012) Development of a Fabric-Reinforced Porous Graft for Vascular Tissue Engineering Using Finite Element Methods and Genetic Algorithms Mark S. Yeoman, B. Daya Reddy, Deon Bezuidenhout, Hellmut C. Bowles, Peter Zilla and Thomas Franz Abstract Small to medium diameter vascular grafts have met with little success over the past 50 years. Surface thrombogenicity and anastomotic intimal hyperplasia, the main reasons for graft failure, are believed to be governed by a lack of endothelialisation and compliance mismatch between graft and host artery.

E. including the values of average recoil and flexibility) and combined with visual assessment of performance, it was decided to select design 17 as the prototype to be manufactured and tested. The width of design 17 was very close to 150 lm. The prototype was manufactured by laser cutting the design from a PLLA tube. Preliminary bench tests demonstrated that the device could be successfully crimped and free-expanded on a balloon-catheter. However, tests of the radial strength of the expanded device revealed a problem in the design, wherein less than satisfactory support was provided at the ends of the device.

I. , Keane, A. : Engineering design via surrogate modelling: a practical guide. Wiley, Chichester (2008) 35. : Finite element shape optimization for biodegradable magnesium alloy stents. Ann. Biomed. Eng. 38(9), 2829–40(2010) 36. : Design and analysis of noisy computer experiments. AIAA J. 44(10), 2331–2339 (2006) 28 N. W. Bressloff 37. : Multidisciplinary and multiobjective design of coronary stents. PhD Thesis, University of Southampton, UK (2012) 38. , Taniike, M. : Initial findings of impact of strut width on stent coverage and apposition of sirolimus-eluting stents assessed by optical coherence tomography.

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