Cardiovascular Hormone Systems: From Molecular Mechanisms to by Michael Bader

By Michael Bader

Edited through a well known scientist within the box with greater than 2 hundred excessive profile medical courses to his identify, this can be the 1st e-book to supply a accomplished review of all cardiovascular hormone structures. sincerely based, the textual content covers steroid and peptide hormones, amines, and arachidonic acid metabolites, to boot as nucleotides, nitric oxide, and acetylcholine. a vital reference for researchers engaged on the cardiovascular procedure and similar ailments.

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Both of these mutations could be described as glucocorticoid hypersensitivity. Conversely, the ER22/23EK polymorphism [168] is associated with glucocorticoid-resistant phenotypes. Carriers display lower total cholesterol and improved insulin sensitivity, and elderly male carriers of the ER22/23EK polymorphism tend to be protected from cardiovascular damage and therefore have improved survival [169]. In young males and females, the ER22/23EK polymorphism is associated with “improved” body shape and lower body weight, compared to age- and sexmatched controls [170].

Endothelial dysfunction can be rescued in the stroke-prone spontaneously hypertensive rat by administration of eplerenone [177]. Aldosterone also plays a major role in Ang II-induced vascular inflammation in the setting of high salt intake [98]. 5 Cardiovascular Effects of Glucocorticoids It is not easy to present a unifying view of the effect of aldosterone on vascular function since the literature is often divergent. It would appear, however, that the net effect of systemic aldosterone is to increase blood pressure by potentiating the action of vasoconstrictors, “activating” VSMCs and increasing sympathetic drive (either directly or indirectly).

And Behnia, R. (2007) Role of renin angiotensin system inhibitors in cardiovascular and renal protection: a lesson from clinical trials. Current Pharmaceutical Design, 13, 1335–45. J. , and van Goor, H. (2007) The emerging role of ACE2 in physiology and disease. Journal of Pathology, 212, 1–11. W. A. (2007) Aliskiren for renin inhibition: a new class of antihypertensives. Annals of Pharmacotherapy, 41, 456–64. A. J. (2006) Hypertension, kidney, and transgenics: a fresh perspective. Physiological Reviews, 86, 709–46.

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