Chirality in Drug Research by Francotte E., Lindner W.

By Francotte E., Lindner W.

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The relevant background work that led to the discovery was accomplished mainly in France during the first half of the 19th century [34]. Hemihedrism in crystals – those of quartz – was first reported by René-Just Haüy (1743–1822), a French priest and crystallographer, in 1801 [35]. Circularly polarized light (often referred to as plane-polarized light) was discovered in 1809 by Étienne Louis Malus (1775–1812), and the physicist François Arago (1786–1853) made the first observation of optical rotation by a substance when he studied the effects of quartz crystals on polarized light [34].

In other words: Is this now an area that has reached a state of maturity and, furthermore, how far have we actually come in incorporating this approach into the toolbox of methodologies? 2), which according to best estimates [7, 13] is under 20, even if there is considerable uncertainty about the absolute figure, then this appears to be a rather exclusive club. When viewed from this perspective, the level of practical utilization is astonishingly low and one could debate the true importance that it represents.

7, p. 3. F. W. A. Sertürner, J. Pharm. 1805, 13, 229–243. F. W. A. Sertürner, Ann. Phys. 1817, 57, 183–202. M. R. Johnson, Analgetics, in M. E. , Wiley-Interscience, New York, 1981, p. 707. See Ref. 20, pp. 708–709, 735. C. P. Eap, T. Finkbeiner, M. Gastpar, N. Scherbaum, K. Powell, P. Baumann, Eur. J. Clin. Pharmacol. 1996, 50, 385–89. M. Honigsbaum, The Fever Trail. In Search of the Cure for Malaria, Farrar, Straus, and Giroux, USA, 2001, pp. 24–25. J. -B. Caventou, Ann. Chim. Phys. 1820, 15.

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