By I. Malek
Non-stop Cultivation of Microorganisms
summary: non-stop Cultivation of Microorganisms
Read Online or Download Continuous Cultivation of Microorganisms. Proceedings of the Second Symposium held in Prague June 18–23, 1962 PDF
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Extra info for Continuous Cultivation of Microorganisms. Proceedings of the Second Symposium held in Prague June 18–23, 1962
This applies also to the question of output. The output of cells from a multi-stream system is given by ¿ ÷ , where x is the concentration of cells issuing from the last fermenter and D the average dilution rate, defined as the sum of all the inflows divided by the sum of all the fermenter volumes. The output therefore depends upon a greater number of independent variables than that of a single-stream system, and cannot be expressed by any simple formula. However, it is not too difficult to see that: (i) the output of a multi-stream system may, according to the ratios of the inputs to the different stages, be either greater or less than that of a single-stage system of the same total volume and operated at the same flow rate; (ii) the maximum possible output of a multi-stream system may equal (though not exceed) that of a one-stage system.
Herber t an d Dr . Powell two questions : Accordin g to our reserc h of alcoholi c an d acetone-butano l fermentatio n wit h simultaneousl y recyclin g of th e microbia l cultur e fro m th e end fermentor s int o th e mai n fermentor , infectio n of th e fermentin g mediu m alway s occurred , sometime s even stoppin g th e fermentatio n process . D o you thin k tha t thi s exampl e shoul d not b e used in your mathematica l generalisation s ? I n th e extrem e case thes e generalisation s mus t be limite d to certai n medi a or processe s which ar e insensitiv e to infection .
W e ha d ourselve s discusse d variou s method s for approximatin g t o a tubula r fermenter , I ha d reache d simila r conclusion s as t o ho w to do it, thoug h we never got aroun d to buildin g one. Wit h regar d t o th e proble m of aeratio n of tubula r fermenters , one can thin k of variou s ways in which thi s could be done , thoug h mor e easily in th e factor y tha n in th e laboratory . On e could , for example , use a meta l tub e an d ru n it unde r pressure , introducin g pur e oxygen at a numbe r of point s alon g th e tube .