By Sylvia Mercado Kierkegaard (ed.)
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Extra resources for Cyberlaw, Security and Privacy
The same pattern of events takes place in the adult after transection of the motor nerve. 4 Schematic of the states of innervation of mammalian skeletal muscle: (top) the initial pattern of superinnervation; (bottom) the adult state where each muscle fibre has contact from a single axon. (After Rasmussen and Willshaw, 1993) single innervation after a few weeks. Muscles vary in size. The soleus muscle is one of the larger muscles in rat with around 3500 fibres innervated by some 25 motor neurons, so that in the adult each motor neuron innervates on average 140 muscle fibres; the rat lumbrical muscle has about 100 muscle fibres and 10 motor neurons.
As mentioned already, modelling is a crucial experimental tool here. To apply computer modelling successfully, models must contain the correct degree of neurobiological realism. The subcellular level Although we now have at our disposal several completely sequenced genomes, we are still for the most part remarkably ignorant about how genes interact and regulate each other to develop the nervous system. A plausible picture of cellular regulation would involve networks of multiple interactions, with feedback between all layers.
All retinotectal maps are arranged so that temporal retina projects to rostral tectum and dorsal retina to medial tectum (Fig. 3b). The problem of understanding how maps are formed was originally formulated in terms of the establishment of a functional relationship between the cells in the two sets of cells. With the advent of powerful methods for tracing patterns of connections, this problem has become that of specifying the connections themselves. One powerful set of results, generated from electrophysiological recordings carried out in the 1970s, involves experiments on the regeneration of connections in the retinotectal system of adult goldfish.