Diseases

Diseases of the Thyroid (Contemporary Endocrinology) by Lewis E. Braverman

By Lewis E. Braverman

This generally revised and up-to-date version of a favored and generally acclaimed paintings offers the newest clinical and medical advancements in thyroid affliction. New themes comprise the medical relevance of the sodium/iodide symporter (NIS), large insurance of autoimmune thyroid ailment, and multiplied insurance of thyroid melanoma, together with recombinant human TSH. different chapters speak about thyroid disorder while pregnant and postpartum, thyroid affliction in young ones and the aged, and the evaluate and administration of nodular goiter. ailments of the Thyroid, 2d variation, offers internists and relations physicians, obstetricians and gynecologists, and endocrinologists alike with a hugely readable advisor to thyroid problems and their scientific administration.

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Integrins are plasma membranespanning molecules stabilized in the plasma membrane by actin microflaments (43). It is possible that TH acts via this route to influence neuronal migration, synapse formation, and morphogenesis (40). It is not yet known whether control of actin polymerization by iodothyronines occurs in cells other than glial cells, nor is it understood whether T4 and rT3 control the cell-surface presentation of proteins other than 5′-DII. It has recently been observed that the density of beta-adrenergic receptors (BAR) on the surface of chick embryonic cardiac myocytes can be increased nongenomically by T3 (24).

Action-potential duration (APD) is prolonged in ventricular myocytes obtained from hypothyroid rats (51). Incubation of hypothyroid cardiomyocytes with 100 nM T3 normalized APD. No hormonal effect on APD was observed when ventricular cells from euthyroid animals were exposed to TH. The action of TH can be viewed as a contribution to the basal APD. Sun has interpreted the mechanism of hormone action to be an effect on the time- and voltage-dependent potassium current (IK), an important determinant of repolarization (51).

Endocrinology 1996;137:4744–4751. 53. Storey NM, O’Bryan JP, Armstrong DL. Rac and Rho mediate opposing hormonal regulation of the ether-ago-go related potassium channel. Curr Biol 2002;12:27–33. 54. Incerpi S, Luly P, deVito P, Farias RN. Short-term effects of thyroid hormones on the Na/H antiport in L-6 myoblasts: high molecular specificity for 3,3′,5-triiodo- L -thyronine. Endocrinology 1999;14: 683–689. 55. Gekle M, Freudinger R, Mildenberger S, Schenk K, Marschitz I, Schramek H. Rapid activation of Na+/H+-exchange in MDCK cells by aldosterone involves MAP-kinases ERK1/2.

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