Disseminated Intravascular Coagulation (DIC): Clinical by Balwinder, M.D. Singh

By Balwinder, M.D. Singh

Disseminated intravascular coagulation is a devastating syndrome characterized by means of the systemic activation of frequent activation of the coagulation cascade and thrombosis, which can bring about critical bleeding and will bring about organ failure. contemporary reports have proven that the occurrence of DIC is lowering, in particular in males. regardless of the advancements in health and wellbeing care supply, the morbidity and mortality because of DIC is still very excessive. This ebook offers an enormous well timed replace at the medical manifestations, very important chance elements, and therapy concepts for DIC, and offers in-depth info on pathophysiological points and numerous diagnostic ratings used to diagnose DIC.

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Extra resources for Disseminated Intravascular Coagulation (DIC): Clinical Manifestations, Diagnosis and Treatment Options

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Other forms of leukaemia have also been linked with DIC, although with a much lower frequency of up to 1-2 %. This is the reason why before initiating chemotherapy in these patients, DIC should be ruled out because the lysis of 24 Akhilesh Kumar Tiwari, Rajiv Ratan Singh, Rishi Raj Sanjay et al. the leukemic cells as a result of chemotherapy may further worsen a sub acute DIC [30]. Other possible mechanism responsible for the DIC in haematological malignancy is profound immunosuppression and neutropenia arising as a result of various forms of therapies for the management of these haematological malignancies, predisposing the patient to various forms of infections like bacterial, viral, fungal or protozoal.

Recombinant TM for Treatment of DIC The recombinant human soluble TM (rhsTM) derived from Chinese hamster ovary (CHO) cells, is composed of the extracellular domain of TM [49]. Similar to membrane-bound native TM, rhsTM retains the ability to bind to thrombin and APC. Administration of rhsTM has been shown to protect rats from tissue factor and endotoxin-induced DIC or lung injury [50-52]. In addition, rhsTM not only reduces compression trauma-induced spinal cord injury by inhibiting leukocyte accumulation and expression of TNF-α [53], but also provides protection against ischemia-reperfusion injury in the liver and kidney [54, 55].

65] Clark SL, Montz FJ, Phelan JP. Hemodynamic alterations associated with amniotic fluid embolism: a reappraisal. Am J Obstet Gynecol 1985; 151: 617-21. [66] Sher G. Pathogenesis and management of uterineinertia complicating abruption placentae with consumptive coagulopathy. Am. J. Obstet Gynecol 1977; 129: 164-70. [67] Jecko Thachil , Cheng-Hock Toh. Disseminated intravascular coagulation in obstetric disorders and its acute haematological management. Blood Reviews 23 [2009] 167–176. [68] Grundy MFB & Craven ER.

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