Public Health

Dompaminergic Neuron Transplantation in the Weaver Mouse by Lazaros C. Triarhou

By Lazaros C. Triarhou

This e-book is the end result of fifteen years of study at the transplantation of dopaminergic neurons within the striatum of the weaver mouse (wv/wv), a neurological mutant characterized
via genetically-determined degeneration of midbrain dopamine neurons. This mutant constitutes the single on hand laboratory version with a protracted affliction that mimics Parkinson's affliction. Structural and practical points of
intrastriatal mesencephalic neuron grafting into the weaver version are reviewed, together with histochemical correlates of graft survival and integration, numerical facets of donor phone survival, ultrastructural findings on
synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor similar molecules, degrees of striatal amino acid receptors, and behavioural results of
unilateral and bilateral neuronal transplantations.

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Dompaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease (Neuroscience Intelligence Unit)

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Extra resources for Dompaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease (Neuroscience Intelligence Unit)

Example text

5. Ultrastructural appearance of tyrosine hydroxylase immunoreactive neuronal somata from a cell suspension graft. Magnification x6500. Reprinted with permission from: Triarhou LC, Brundin P, Doucet G et al. Exp Brain Res 1990; 79:3-17. © Springer-Verlag. 37 One may therefore estimate that each side of the normal mouse striatum derives its innervation from approximately 1700 nigral DA cells. In the weaver condition that innervation would originate from the 500 DA cells that remain in the ipsilateral substantia nigra.

4. Norman RM. Primary degeneration of the granular layer of the cerebellum: An unusual form of familial cerebellar atrophy occurring in early life. Brain 1940; 63:365-379. 5. Jervis GA. Early familial cerebellar degeneration (Report of three cases in one family). J Nerv Ment Dis 1950; 111:398-407. 6. Jervis GA. Concordant primary atrophy of the cerebellar granules in monozygotic twins. Acta Genet Med Gemellol 1954; 3:153-162. 7. Norman RM, Urich H. Cerebellar hypoplasia associated with systemic degeneration in early life.

Sequence of developmental abnormalities leading to granule cell deficit in cerebellar cortex of weaver mutant mice. J Comp Neurol 1973; 152:103-132. 67. Smeyne RJ, Goldowitz D. Development and death of external granular layer cells in the weaver mouse cerebellum: A quantitative study. J Neurosci 1989; 9:1608-1620. 68. Smeyne RJ, Goldowitz D. Postnatal development of the wild-type and weaver cerebellum after embryonic administration of propylthiouracil (PTU). Dev Brain Res 1990; 54:282-286. 69. Wiestler OD, Trenkner E, Walter G.

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