Nonfiction 1

Dopaminergic Neuron Transplantation in the Weaver Mouse by Lazaros C. Triarhou (auth.)

By Lazaros C. Triarhou (auth.)

This e-book is the fruits of fifteen years of study at the transplantation of dopaminergic neurons within the striatum of the weaver mouse (wv/wv), a neurological mutant characterised through genetically-determined degeneration of midbrain dopamine neurons. This mutant constitutes the single on hand laboratory version with a protracted ailment that mimics Parkinson's ailment. Structural and sensible features of intrastriatal mesencephalic neuron grafting into the weaver version are reviewed, together with histochemical correlates of graft survival and integration, numerical features of donor mobilephone survival, ultrastructural findings on synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor similar molecules, degrees of striatal amino acid receptors, and behavioural results of unilateral and bilateral neuronal transplantations.

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C. TRlARHOU Figure 11. Autoradiography of[lHlmazindol binding to +1+ (upper) and wvlwv(lower) forebrain. Binding signal in the wild-type is dense throughout the entire striatum. In the weaver striatum, binding is severely reduced. especially in the dorsal striatal complex. Magnification x12. Reprinted with permission from: Stotz EH, Palacios JM, Landwehrmeyer Bet aU Neural Transm [Oen Sectll994; 97:51-64. © SpringerVerlag. Neuron losses in the mesencephalic DA cell groups lead to DA deficiency in several telencephalic areas to which A8, A9, and AIO normally supply DA innervation.

Willinger M, Margolis DM. Effect of the weaver (wv) mutation on cerebellar neuron differentiation. I. Qualitative observations of neuron behavior in culture. Dev Bioi 1985; 107:156-172. 105. Willinger M, Margolis DM. Effect of the weaver (wv) mutation on cerebellar neuron differentiation. II. Quantitation of neuron behavior in culture. Dev Bioi 1985; 107:173-179. 106. Hatten ME, Liem RKH, Mason CA. Weaver mouse cerebellar granule neurons fail to migrate on wild-type astroglial processes in vitro.

78. Schweitz H, Heurteaux C, Bois P et al. Caleicludine, a venom peptide of the Kunitz-type protease inhibitor family, is a potent blocker of high-threshold Ca2 + channels with a high 40 79. 80. 81. 82. 83. 84. 85. 86. 87. 88. 89. 90. 91. 92. 93. 94. 95. 96. 97. 98. C. TRIARHOU affinity for L-type channels in cerebellar granule neurons. Proc Nat! Acad Sci USA 1994; 91: 878-882. Salinas PC, Copeland NG, Jenkins NA et al. Maintenance of Wnt-3 expression in Purkinje cells of the mouse cerebellum depends on interactions with granule cells.

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