By Sanjeev Saksena, John Camm, Penelope Boyden, Paul Dorian, Nora Goldschlager
This brand-new source makes a speciality of the typical scientific positive factors, analysis, and administration of the total variety of rhythm issues, highlighting simple technology purely the place worthy. To-the-point and useful, this article discusses every thing from cardiac rhythms and arrhythmias...to sickness states linked to cardiac arrhythmias...to the newest pharmacologic and interventional therapies.Outlines the typical scientific good points of rhythm issues and the way to regard and deal with them. encompasses a mini-textbook of mechanisms, id, research, and diagnosis for many universal arrhythmia kinds within the part on rhythms and arrhythmias.Provides administration options for advanced sufferer problems.Discusses scorching subject matters comparable to genetics and cardiac arrhythmias, Brugada syndrome, and units for the administration of atrial traumatic inflammation.
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Extra info for Electrophysiological Disorders of the Heart
When the depolarizing current becomes available to Molecular and Cellular Basis of Cardiac Electrophysiology 21 of cardiac rhythm. However, an exclusively molecular approach to understanding arrhythmia mechanisms is limited by failure to include cellular and network properties of the heart. We attempt to place in context the role of cellular and molecular changes in the development of clinically significant rhythm disturbances. A summary of the cellular and molecular changes that underlie prototypic arrhythmias and their putative mechanisms is shown in Table 1-3.
Van Wagoner DR, Pond AL, Lamorgese M, et al: Atrial L-type Ca2+ currents and human atrial fibrillation [see comments]. Circ Res 1999;85:428-36. Vassort G, Alvarez J: Cardiac T-type calcium current: Pharmacology and roles in cardiac tissues. J Cardiovasc Electrophysiol 1994;5:376-93. Bers DM, Perez-Reyes E: Ca channels in cardiac myocytes: Structure and function in Ca influx and intracellular Ca release. Cardiovasc Res 1999;42:339-60. Beuckelmann DJ, Nabauer M, Erdmann E: Characteristics of calcium-current in isolated human ventricular myocytes from patients with terminal heart failure.
If the area of conduction block is short and the magnitude of the electrotonic current (source) is sufficiently large, the segment of tissue distal to the blocked area (sink) will be excited but with a significant delay. With the appropriate relationship of the electronic current transmitted through the inexcitable segment and distal excitable tissue, the distal segment can not only be activated but it can reactivate the proximal segment of muscle by electronic current flow from distal to proximal segments.