Pharmacy

Freeze-Drying/Lyophilization of Pharmaceutical and by Louis Rey, Joan C. May

By Louis Rey, Joan C. May

Completely acquainting the reader with freeze-drying fundamentals-including water houses severe to the method and mechanisms and technique of protein stabilization-Freeze-Drying/Lyophilization of Pharmaceutical and organic items, moment variation carves useful instructions from the very most modern theoretical study, applied sciences, and commercial procedures-ensuring the simplest execution of steps from closure training and regulatory keep watch over of goods to gear sterilization and method validation.

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J Biol Chem 265(35):21971–21978 Kim IG, McBride OW et al (1992) Structure and organization of the human transglutaminase 1 gene. J Biol Chem 267(11):7710–7717 Kim SY, Kim IG et al (1994) The structure of the transglutaminase 1 enzyme. Deletion cloning reveals domains that regulate its specific activity and substrate specificity. J Biol Chem 269 (45):27979–27986 Kiraly R, Csosz E et al (2009) Functional significance of five noncanonical Ca2+Àbinding sites of human transglutaminase 2 characterized by site-directed mutagenesis.

J Mol Model 13(1):233–246 Boothe RL, Folk JE (1969) A reversible, calcium-dependent, copper-catalyzed inactivation of guinea pig liver transglutaminase. J Biol Chem 244(2):399–405 Boscolo S, Lorenzon A et al (2010) Anti transglutaminase antibodies cause ataxia in mice. PLoS One 5(3):e9698 Candi E, Paradisi A et al (2004) Transglutaminase 5 is regulated by guanine-adenine nucleotides. Biochem J 381(Pt 1):313–319 Cardoso I, Stamnaes J et al (2015) Transglutaminase 2 interactions with extracellular matrix proteins as probed with celiac disease autoantibodies.

Based on the fact that the FXIIIa crystal contains three calcium ions and that its model can accommodate both substrates and displays an active site fully compatible with the putative catalytic mechanism, the TGM2 structures may not represent a fully activated state and the FXIIIa model may approach that situation better. It is interesting to ponder whether in a physiological context, when an activating calcium surge is on decline, Tgases may release the metal and adopt a stable conformation corresponding to the linear open form.

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