Freeze-Drying Lyophilization Of Pharmaceutical & Biological by Louis Rey, Joan C. May

By Louis Rey, Joan C. May

Completely acquainting the reader with freeze-drying basics, Freeze-Drying/Lyophilization of Pharmaceutical and organic items, moment Edition carves useful directions from the very newest theoretical study, applied sciences, and business strategies. It delineates the easiest execution of steps from closure instruction and regulatory keep watch over of goods to apparatus sterilization and strategy validation. With thirteen new chapters supplying cutting-edge info, the booklet unveils ideas presently advancing the sector, together with LYOGUARD® packaging for bulk freeze-drying and the irradiation of pharmaceutical and organic items.

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Extra info for Freeze-Drying Lyophilization Of Pharmaceutical & Biological Products, Second Edition: Revised And Expanded (Drugs and the Pharmaceutical Sciences)

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Cadarache, France). Thus, a high dose (30 kGy ¼ 3 Mrad) is delivered in a short time (45 min). 5 C/min) to room temperature. , and emit light when the excited states go back to the fundamental level. In some experiments we have been able to record the frequency spectrum of the glow thanks to a high-performance digital CCD camera coupled with a visible- to near-IR ACTON spectrograph (Princeton Instruments). 2. Results It is generally assumed that the thermoluminescence centers are located preferentially in the defects of the crystalline network and that those defects, in turn, are a mere reflexion of the structure of the original liquid.

This process yielded deuterated C-phycocyanin proteins (d-CPC) that had virtually all the 1H–C bonds replaced by 2H–C bonds. One can obtain a lyophilized sample that is similar Copyright 2004 by Marcel Dekker, Inc. All Rights Reserved.

Copyright 2004 by Marcel Dekker, Inc. All Rights Reserved. This chapter looks at the appropriate strategy to be developed to obtain some understanding of the behavior of water close to a biological macromolecule, as presented in the following. In the last few years, computer simulations and theoretical treatments of the structure and dynamics of water in different kinds of environments have been undertaken [32–41]. Some important results are now available. 5 g/cm3 in the first few angstroms of the shell around a protein and give information concerning the pair correlation functions and orientations of water molecules [42].

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