Diseases

Gastrointestinal Malignancies by David Bentrem, Al B. Benson

By David Bentrem, Al B. Benson

This e-book comprehensively summarizes the present country of data on malignancies of the gastrointestinal tract. committed organ-based chapters overview present remedies and administration and supply info on prevalence, etiology and organic features. The cutting-edge within the radiologic and endoscopic staging of gastrointestinal malignancies is defined, and counsel is obtainable at the position of interventional radiology and interventional gastroenterology within the remedy of those tough tumors. additionally, the ebook explores novel and evolving remedies, together with custom-made systemic remedy and minimally invasive surgical and radiology ideas, and addresses patient-reported results and survivorship demanding situations. It closes by way of discussing animal types of gastrointestinal malignancies and interpreting the importance of the Ras superfamily of GTPases. it will likely be of gain to all surgeons, oncologists and different experts who deal with those malignancies, in addition to to trainees seeking to elevate their figuring out of the field.

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J Am Coll Surg 205(4 Suppl):S49–S53 56. Sobin LH et al (2011) TNM classification of malignant tumours, 7th edn. Wiley-Blackwell, Oxford, UK 57. Taniere P et al (2002) Cytokeratin expression in adenocarcinomas of the esophagogastric junction: a comparative study of adenocarcinomas of the distal esophagus and of the proximal stomach. Am J Surg Pathol 26:1213–1221 58. Torres CM et al (1999) Pathologic prognostic factors in esophageal squamous cell carcinoma: a follow-up study of 74 patients with or without preoperative chemoradiation therapy.

Malignant clinical behavior is seen in approximately 30 % of GISTs; local recurrence, peritoneal spread, and liver metastases comprises a common course for the disease [7, 24, 25]. Generally accepted prognostic factors for GISTs include patient age, tumor site, mitotic rate, nuclear atypia, tumor cellularity, tumor size, necrosis, and invasive growth pattern (Table 2) [6, 13, 24, 25, 36]. Prior to their immunohistochemical and molecular characterization, GISTs were historically labeled as various other tumors of smooth muscle or neurogenic origin, namely leiomyomas, leiomyosarcomas, and schwannomas.

Sarbia M et al (1995) Incidence and prognostic significance of vascular and neural invasion in squamous cell carcinomas of the esophagus. Int J Cancer 4, 61(3):333–6 53. Serrano J et al (2000) Alterations in the p16INK4a/CDKN2A tumor suppressor gene in gastrinomas. J Clin Endocr Metab 85:4146–4156 54. Shimada H et al (2003) Treatment response and prognosis of patients after recurrence of esophageal cancer. Surgery 133(1):24–31 55. Siewert JR et al (2007) Adenocarcinoma of the esophagogastric junction: competition between Barrett and gastric cancer.

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