Cardiology

Genetics of Cardiovascular Disease by Tim Chico

By Tim Chico

This quantity of the esteemed Progress in Molecular Biology and Translational Science sequence specializes in state-of-the-art study with regards to the genetics of heart problems. Written via most sensible specialists within the box, this quantity covers a number of themes, together with:

  • Genetic types of atherosclerosis
  • MicroRNAs in cardiovascular disease
  • The function of the transcription issue KLF2 in vascular improvement and disease
  • Zebrafish as versions of heart problems and hematopoietic improvement

Progress in Molecular Biology and Translational Science presents a discussion board for dialogue of latest discoveries, techniques, and concepts in molecular biology. It comprises contributions from leaders of their fields and plentiful references.

Key features:

  • The authors are all specialists within the field
  • The studies are in themselves comprehensive
  • Each subject has the aptitude to steer to advances in remedy of heart problems

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Example text

42. Lindsay EA, Su H, Morishima M, et al. Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice. Nature. 2001;410:97–101. 43. Jerome LA, Papaioannou VE. DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. Nat Genet. 2001;27:286–291. 44. Merscher S, Funke B, Epstein JA, et al. TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell. 2001;104:619–629. 45. van den Boogaard M, Wong LY, Tessadori F, et al. Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer.

43. Jerome LA, Papaioannou VE. DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. Nat Genet. 2001;27:286–291. 44. Merscher S, Funke B, Epstein JA, et al. TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell. 2001;104:619–629. 45. van den Boogaard M, Wong LY, Tessadori F, et al. Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer. J Clin Invest. 2012;122(7): 2519–2530. 46. Christoffels VM, Hoogaars WM, Tessari A, Clout DE, Moorman AF, Campione M.

Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome. Nat Genet. 1997;15:30–34. 96. Li QY, Newbury-Ecob RA, Terrett JA, et al. Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family. Nat Genet. 1997;15:21–35. K. A. Chico, Allan Lawrie Department of Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom Contents 1. 3 MicroRNA 2. 3 Cellular localization of miRNA 3. 7 miRNA, inflammation, and BMPR2 signaling 4. Conclusions and Future Directions Acknowledgments References 44 44 45 45 47 48 48 50 50 53 54 54 55 55 57 57 59 60 60 Abstract MicroRNA (miRNA) are short noncoding RNA that regulate gene expression by inhibiting translation or promoting degradation of target mRNA.

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