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Het Syndroom van Gilles de la Tourette: Klinische Bevindingen. Nederlands Tijdschrijte voor Geneeskunde 1988; 132:21–25. 53. Burd L, Kerbeshian J, Klug MG, Barth A, Avery PK, Benz B. Long-term followup of an epidemiologically defined cohort of patients with Tourette syndrome. J Child Neurol 2001; 16:431–437. 4 Obsessive-Compulsive Disorder and Self-Injurious Behavior Valsamma Eapen UAE University United Arab Emirates and University College London Medical School London, England Jessica W. Yakeley Maudsley Hospital London, England Mary May Robertson The National Hospital for Neurology and Neurosurgery and University College London Medical School London, England INTRODUCTION In this chapter, we discuss obsessive-compulsive disorder (OCD), self-injurious behavior (SIB), and their relationships to Gilles de la Tourette’s syndrome (TS).

22 for women per 10,000. Projecting from these figures, the investigators estimated that there were approximately 33,000 children and only 8000 adults with TS in the United States. On the basis of these findings, it can be stated with assurance that the tic symptomatology of TS is ameliorated with age. After a review of the multitude of studies that have been done, a very general conclusion may be drawn that approximately one third of cases will remit completely during late adolescence or early adulthood, another third will show a significant improvement (in both amount and severity) of tics, whereas the remaining third will continue to be symptomatic throughout early adulthood and middle age (12).

According to his experience, he argued that the TS patient suffers from an oppressive hyperawareness of what his or her skin, muscles, and joints feel like, because of deficient attentional inhibition. ’’ ‘‘If all tics are suppressed, virtually all my joints and muscles begin to demand my attention. The TS state heightens to a stiffening feeling, such that my skin feels like a Premonitory ( ’’Sensory ’’) Experiences 19 hardened casing and my joints feel as though they are becoming rigid. ’’ Cohen and Leckman (4) also described a similar concept of ‘‘site sensitization’’ in 13 of 20 (65%) of patients with TS questioned about whether or not they felt that they had heightened sensitivity to sensory stimuli.

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