Modelling the Short QT Syndrome Gene Mutations: And Their by Ismail Adeniran

By Ismail Adeniran

The brief QT Syndrome (SQTS) is characterised by way of abbreviated QT durations at the electrocardiogram, elevated threat of cardiac arrhythmias and surprising loss of life. even supposing a number of gene mutations were pointed out in SQT sufferers, the function of those mutations in selling arrhythmogenesis remains to be no longer thoroughly understood. hence, this thesis employs multidisciplinary methods to increase a 3D digital center, that's then used to explain how the fast QT syndrome enables and continues ventricular arrhythmias and to figure out its results on ventricular mechanical contraction. The findings during this thesis offer a complete and mechanistic cause of a couple of gene mutations linked to potassium channels when it comes to susceptibility to arrhythmia. The multiphysics types built supply a robust platform for opting for the foundation motives of varied arrhythmias and investigating healing interventions for those diseases.

The thesis was once tested via Prof. Chris Huang of the college of Cambridge, the main authoritative determine in cardiac electrophysiology, who has defined the paintings as “outstanding.”

Show description

Read or Download Modelling the Short QT Syndrome Gene Mutations: And Their Role in Cardiac Arrhythmogenesis PDF

Similar cardiology books

Transplant-Associated Coronary Artery Vasculopathy

A evaluation of transplant linked coronary affliction as a multifactorial affliction contributed to by way of genetic elements within the donor and recipients, occasions taking place in the course of mind demise, harvesting and implantation and most significantly occasions after transplantation.

Pediatric Hypertension

This multidisciplinary evaluate of all facets of pediatric high blood pressure is the main cutting-edge therapy of the topic presently to be had. the subjects lined variety from the rules and evaluation of blood strain in little ones, to its overview and day by day administration. The authors not just define the pathophysiology of high blood pressure in kids, but additionally provide present info on blood strain size, the right kind suggestions for prognosis, the review of hypertensive finish organ harm even in formative years, and using ambulatory blood strain tracking.

Complications in Endovascular Therapy

Exploring novel tools in endovascular intervention, this reference offers exact insurance of concepts to prevent, deal with, and regulate issues in endovascular treatment with chapters via world-renowned pioneers and experts practiced within the prevention and keep an eye on of vascular and machine issues.

Super-Selective Arteriography of the External Carotid Artery

It used to be a very good honour and a mark of our friendship that RENE DJINDJIAN requested me to give this new paintings from the Lariboisiere neuroradiological university. Professor DJINDJIAN died on eleventh October. Introducing this publication now, i think that i'm facing a fatherless baby, the place emotions of admiration and enjoyment are combined with the unhappiness of the loss and the bitterness of an unfinished job.

Additional resources for Modelling the Short QT Syndrome Gene Mutations: And Their Role in Cardiac Arrhythmogenesis

Sample text

HERG/ IKr and KCNQ1-KCNE1/IKs pass current preferentially in the outward direction while KCNJ2/IK1 passes current preferentially in the inward direction over the outward direction. 2 The hERG/IKr Potassium Channel The significance of the hERG/IKr channel for normal human cardiac electrical activity was discovered when inherited gene mutations to hERG resulted in long QT syndrome (LQTS) [12–14]; a cardiac repolarization disorder. In the LQTS, patients have a lengthened QT interval on the ECG and become susceptible to the potentially fatal arrhythmia torsades de pointes [15–17].

Of all the K+ channels, it has the highest selectivity for K+ ions [24, 57]. 2 Acetylcholine-Activated K+ Channel (IK,Ach) IK,Ach is highly expressed in the SAN, AVN and atria cells but has low expression in the ventricle [22, 24, 57]. Its activation by acetylcholine results in a weakly inward-rectifying K+ current (inward rectification is weaker than that for IK1) that hyperpolarises the cell and shortens the APD. It is activated when acetylcholine binds to the M2 muscarinic receptor, which is coupled to the K+ channel via the guanine nucleotide binding protein (G protein) [22, 24, 57].

Potentials positive to EK (see red 42 2 Potassium Channels Implicated Fig. 1 channel expressed in HEK cells elicited by the ascending voltage ramp command shown inset. Modified from [93] line in Figs. 9) [86–88, 94–97]. As membrane depolarisation increases further, the outward IK1 current decreases due to its inward rectification. , the SAN [98]. e. membrane potential is more ‘labile’ in the absence of IK1). Consequently, in cardiac cells, IK1 plays a role in stabilizing the resting potential of the cell and in the duration of the action potential [86–88, 94– 97].

Download PDF sample

Rated 4.57 of 5 – based on 13 votes