Pediatric Drug Development by Andrew E. Mulberg, Lisa L. Mathis, Dianne Murphy, Julia

By Andrew E. Mulberg, Lisa L. Mathis, Dianne Murphy, Julia Dunne

Pediatric Drug Development, moment variation, encompasses the recent regulatory tasks throughout ecu, US and ROW designed to motivate better entry to secure and powerful drugs for kids. It contains new advancements in biomarkers and surrogate endpoints, developmental pharmacology and different novel points of pediatric drug improvement.

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6 million children (9%) in 1998 [20]. 2 World It is estimated that 36% of the total global disease and injury burden involves children under 15. This disease burden is almost entirely in low and middle income countries. 2 million) [23]. Although current global public health concerns focus on acute illnesses, especially in children under age 5, that toll is expected to decline by half by 2025. In contrast, the proportion of chronic diseases such as depression and cardiovascular illness throughout the world is expected to rise from 55% in 1990 to 73% in 2020, with the most rapid increase expected in the developing world [24].

For children living with cancer, 80% of whom live in low and middle income countries where there is a higher risk of death because of late diagnosis or lack of treatment, palliative care is vital [129]. However, access to such palliative care facilities and services is limited; as of 2012, very few countries have evidence of broad palliative care provision for children with focused plans for the development of services [133]. 1 million illegal immigrants were living in the US. 8% were born outside the US [140].

2 World More therapeutic options for children are clearly needed. e. lacking a specific indication for use in children) [130]. According to a study published in the American co-occurring conditions [115]. The use of psychostimulant drugs to treat ADHD tripled between 1993 and 2003, while global spending increased nine-fold (adjusted for inflation). In 1993, 31 countries had adopted the use of ADHD medications, and this number grew to 55 by 2003. Among Organization for Economic Cooperation and Development (OECD) countries, use of ADHD medications is positively correlated with increasing gross domestic product (GDP).

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