Pharmaceutical applications of Raman spectroscopy by Slobodan Sasic, Sean Ekins

By Slobodan Sasic, Sean Ekins

Raman spectroscopy has complex lately with expanding use either in and academia. this can be due principally to regular advancements in instrumentation, lowering expense, and the supply of chemometrics to help within the research of information.

Pharmaceutical purposes of Raman spectroscopy have constructed equally and this ebook will concentrate on these purposes. rigorously prepared with an emphasis on matters, Pharmaceutical purposes of Raman Spectroscopy, presents the elemental thought of Raman impression and instrumentation, after which addresses quite a lot of pharmaceutical functions. present functions which are sometimes used in addition to people with promising strength are lined. functions conceal a huge variety from discovery to production within the pharmaceutical and contain deciding upon polymorphs, tracking real-time techniques, imaging stable dosage formulations, imaging energetic pharmaceutical constituents in cells, and diagnostics.

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Finally, there are techniques that make use of the fact that CCDs with rectangular active areas are widely available, which raises the possibility of recording more than one spectrum on the detector by offsetting data channels vertically. Commercial systems that use specially prepared diffraction gratings with two sets of lines to direct two different spectral ranges onto the detector simultaneously have been available for several years. A more extreme version of this concept is the use of echelle spectrometers, which contain two diffraction gratings, oriented so that they disperse light in orthogonal directions.

For studies of solid dosage forms using FT spectrometers, resolutions between 1 and 8 cmÀ1 are typical. , 1997); but in most published studies, the reasons for choosing a particular resolution are often not explicitly discussed and may be set as much by local practice as a conscious decision. In part, this is probably because although there is always a balance to be struck between sensitivity and resolution (any attempts to increase resolution will be at the expense of longer exposure times to achieve the same S/N) the balance is not finely poised.

2002) Okumura and Otsuka (2005) Auer et al. (2003) Roberts et al. (2002) Rantanen et al. (2005) Al-Zoubi et al. (2002) Pratiwi et al. (2002) De Spiegeleer et al. (2005) 32 PHARMACEUTICAL APPLICATIONS OF RAMAN SPECTROSCOPY primarily intended to give a general impression of the range of samples for which quantitative Raman analysis methods have been developed and the methods currently being employed. No strenuous effort has been made to make this a comprehensive list; partly because such tables very quickly become obsolete but mostly because researchers who require compound-specific information will undoubtedly use electronic literature searching methods whether a table contains their compound of interest or not.

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