Pharmacy

Pharmaceutical dosage forms: parenteral medications. Volume by Sandeep Nema, John D. Ludwig

By Sandeep Nema, John D. Ludwig

This three-volume set of Pharmaceutical Dosage kinds: Parenteral Medications is an authoritative, complete reference paintings at the formula and manufacture of parenteral dosage types, successfully balancing theoretical concerns with the sensible features in their improvement. As such, it is strongly recommended for scientists and engineers within the pharmaceutical and academia, and also will function a very good reference and coaching instrument for regulatory scientists and caliber coverage professionals.

First released in 1984 (as volumes) after which final revised in 1993 (when it grew to 3 volumes), this most recent revision will deal with the plethora of adjustments within the technology and substantial advances within the know-how linked to those items and routes of management. The 3rd version of this booklet continues the positive factors that made the final variation so well known yet contains numerous fresh chapters, revisions to all different chapters, in addition to top of the range illustrations.

Volume one presents:

  • A old point of view of injectable drug treatment, universal routes of management, and biopharmaceutics of NCEs and NBEs.
  • An in-depth dialogue at the preformulation and formula of small and big molecules, together with ophthalmic dosage forms.
  • A presentation of parenteral basic packaging strategies - glass and plastic bins, in addition to elastomeric closures.
  • A definitive bankruptcy on container-closure integrity.
  • New chapters on solubility and solubilization, formula of depot supply platforms and biophysical/biochemical characterization of proteins.

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Additional resources for Pharmaceutical dosage forms: parenteral medications. Volume 1, Formulation and packaging

Example text

3d] [2/7/010/12:12:12] [7–29] PARENTERAL DRUG ADMINISTRATION: ROUTES OF ADMINISTRATION AND DEVICES Figure 6 17 Schematic representation of an intrathecal administration (A) epidural route; (B) intrathecal route. spasticity in people with cerebral palsy for whom other procedures, such as rhizotomy or orthopedic surgery, are inappropriate. The same precautions required for intraventricular administration apply to use of the intrathecal route. In addition, a real threat of tonsilar or brain stem herniation (and possibly death) exists if this procedure is performed while intracranial pressure is elevated.

The needle, which is a special blunt, openended needle, is passed through the frontal lobe into the lateral ventricle. When repeated injections or infusions are required, use of an Ommaya (15) or Rickam (16) reservoir or similar silicone, elastomer, SC reservoir is recommended. Surgical placement of the reservoir may be accomplished in a variety of ways. Often with these devices no local anesthetic is required for reinjection, and the system may be sampled and injected repeatedly with minimum disturbance to the patient and with reduced risk of infection.

Elastomeric infusion pumps are disposable devices, in which the pressure on the fluid is generated by the force of a stretched elastomer. Elastomeric disposable pumps consist of an elastomeric membrane, which contains the drug that is contained within an outer protective shell. , Infusor1). A soft elastomeric outer shell offers less protection against sharps puncture but requires less storage and disposal space. , isoprene rubber, latex, and silicon), and can be made of a single or multiple layers.

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