Pharmaceutical Dosage Forms: Tablets: Unit Operations and by Larry L. Augsburger, Stephen W. Hoag

By Larry L. Augsburger, Stephen W. Hoag

Pharmaceutical Dosage kinds: drugs, quantity 1 examines the basic actual and chemical procedures that different unit oprations use, after which applies this data to the dialogue of the various unit operations and procedures.

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11 Schematic of cell division. 3 Basics of Biology j23 hybridizing the genetic information from a tumor cell and a different desired cell line. Cells die after reaching their species-specific lifespan (apoptosis) and are prone to mutation. This spontaneous variation of genetic informa- Genetic stability tion can be caused by transmission errors during DNA replication as well as other factors. e. the transfer performance of genetic information from generation to generation) is an important criterion for the evaluation of a modified cell line.

1). Proteins with similar primary and secondary structure, but different tertiary structure, usually show completely different functionalities. The grouping of Aggregation equal molecules – denoted as aggregate formation – can also have a positive or negative effect on therapeutic biological activity. Unfolding of the protein is also referred to as ‘denaturation’, mean- Denaturation ing the destruction of the three-dimensional structure, and typically goes along with a loss of biological activity.

A significant drawback with using animals is the risk of viral transfer to humans. Transgenic systems are not yet as far developed as microbial or mammalian systems. Their high productivity leads them to be regarded as being competitors to mammalian systems. There are, however, questions of genetic stability and GMP compliance of animal husbandry or plant breeding respectively. In recent years, mammalian cell systems have dramatically developed and platform technologies with high expression rates have been established, so that it can be questioned whether transgenic systems will prevail in the long run.

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