Plague by Donald Emmeluth, I. Edward Alcamo, David Heymann

By Donald Emmeluth, I. Edward Alcamo, David Heymann

Specializes in the ailment from a molecular and organic perspective, discussing affliction transmission and replication, in addition to its results at the physique and treatment/prevention tools.

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Some of the bacteria go into macrophages, you get an influx of PMNs and then inflammation. Part of inflammation is fluid influx, so your lungs fill up and you can’t breathe,” says Straley. “The bacteria also spread to the lymph nodes and the blood, so the basic process is the same as in bubonic plague, but we really know very little about the specifics. ” Straley adds that this is a very narrow window for correct diagnosis and treatment. Septicemic plague may occur as a complication of either bubonic or pneumonic plague.

A definitive diagnosis is made when the organisms are cultured on various microbiological media such as blood agar, MacConkey agar, or infusion broth. Y. pestis does not have many enzymatic functions, such as adenine deaminase, aspartase, ornithine decarboxylase, glucose-6-phosphate dehydrogenase, and urease. It primarily utilizes glucose and mannitol, and cannot ferment most carbohydrates. It grows on sheep blood agar with little or no hemolysis, and forms gray-white colonies with a shiny appearance after about 48 hours.

To help prevent the possible spread of dangerous diseases, like plague, that might be used as weapons, a complex system called the Laboratory Response Network has been set up to track the course of plague and other illnesses in unusual situations. From the initial report of the disease, the conditions and risks are assessed by more and more specialized laboratories until the situation is firmly understood and under control. q 7/22/04 11:01 PM Page 45 Diagnosis academic laboratories. They require BSL-4 safety equipment and practices.

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