By Maria Alejandra Alvarez
In this ebook emphasis should be installed the relevance of Plant Biotechnology for generating compounds of pharmaceutical and commercial relevance in particular the contribution of in vitro plant mobile cultures for generating recombinant proteins (molecular farming) and compounds produced through crops beneficial for human and animal well-being (secondary metabolites) might be mentioned. additionally the outline of a few technique held by way of entire crops could be integrated. the purpose might be to supply appropriate theoretical frameworks and the newest empirical learn findings for execs and researchers operating within the box of Plant Biotechnology, molecular farming and biochemical engineering.
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Whereas the genomic revolution has quick resulted in the deposit of greater than 30,000 constructions within the protein info financial institution (PDB), below one percentage of these contributions signify membrane proteins although membrane proteins represent a few 20 percentage of all proteins. This discrepancy turns into considerably complex while it truly is coupled with the truth that 60 percentage of present medications are in line with focusing on this workforce of proteins, a pattern that doesn't look prone to opposite.
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Additional resources for Plant Biotechnology for Health: From Secondary Metabolites to Molecular Farming
Biochem Pharmacol 71:818–826 Park SU, Yu M, Facchini PJ (2003) Modulation of berberine bridge enzyme levels in transgenic root cultures of California poppy alters the accumulation of benzophenathridine alkaloids. Plant Mol Biol 51:153–164 Patra B, Schlutternhofer C, Wu Y, Pattanaik S, Yuan L (2013) Transcriptional regulation of secondary metabolite biosynthesis in plants. Biochim Biophys Acta 1829:1236–1247 Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N et al (2008) Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
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Since the 1980s, in vitro cultures became an important tool in basic and applied studies generating knowledge on plant metabolism and on the optimization of productive processes of metabolites in plant cells (phytofermentations). In a first period, research was mainly focused on the production of plant natural products by in vitro cultures of a specific species. : recombinant proteins). Chapter 6 of this book describes the application of in vitro cultures for molecular farming, which is the production of heterologous proteins of commercial interest in GMOs as transgenic plants.