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Practical Gastroenterology and Hepatology: Small and Large by Nicholas J. Talley, Sunanda V. Kane, Michael B. Wallace

By Nicholas J. Talley, Sunanda V. Kane, Michael B. Wallace

This finished source for fellows/trainees and applicants for recertification in gastroenterology summarizes the sector in a contemporary, clean layout. favorite specialists from worldwide write on their parts of workmanship, and every bankruptcy follows a uniform constitution. the point of interest is on key wisdom, with crucial medical evidence highlighted in containers. colour illustrations strengthen the textual content.

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Gastroenterology 1983; 84: 924–7. 19 Delvalle J, Yamada T. The gut as an endocrine organ. Annu Rev Med 1990; 41: 447–55. 20 Leiter AB, Chey WY, Kopin AS. Secretin. In: Walsh JH, Dockray GJ, eds. Gut Peptides: Biochemistry and Physiology. New York: Raven Press, 1994: 144. 21 Li P, Lee KY, Chang TM, Chey WY. Mechanism of acidinduced release of secretin in rats. Presence of a secretinreleasing peptide. J Clin Invest 1990; 86: 1474–9. 22 Brady CE 3rd. Secretin provocation test in the diagnosis of Zollinger-Ellison syndrome.

1 Neuropeptide families. Family Hormones Secretin Secretin, glucagon, glucagon-like peptides, VIP, peptide histidine isoleucine, growth hormone-releasing hormone, pituitary adenyl cyclase-activating peptide Insulin Insulin, insulin-like growth factors I and II, relaxin Epidermal growth factor Epidermal growth factor, transforming growth factor-α, amphiregulin Gastrin Gastrin, CCK, cerulean, cionin Pancreatic polypeptide-fold Pancreatic polypeptide, peptide YY, neuropeptide Y Tachykinin Substance P, neurokinins Somatostatin Somatostatin, corticostatin Ghrelin Ghrelin, motilin CCK, cholecystokinin; VIP, vasoactive intestinal peptide.

The ultrastructure and basic biochemistry of both gastrointestinal smooth muscle and nerve cells have been examined in detail and the complex properties of the enteric nervous system and its interactions with the autonomic and central nervous systems revealed [3–5]. Gut motor function is regulated by an elaborate neurohumoral system. Levels of control include: gut muscle, through its intrinsic properties and the close connections (nexi) that exist between individual smooth muscle cells, interstitial cells CHAPTER 5 Motor and Sensory Function of Cajal (ICCs), acting as pacemakers in the small intestine and colon, the enteric nervous system, the extrinsic (autonomic) nervous input to the gut, and the central nervous system (CNS).

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