Diseases

Protozoans in Macrophages by Eric Denkers

By Eric Denkers

Utilizing as a subject the come upon among protozoan parasites and macrophages, this quantity brings jointly mobile biologists, immunologists and protozoologists to study present advancements during this extensive and dynamic study quarter. mentioned are methods protozoans identify their intracellular area of interest, how they turn on macrophage effector features, what those features are, and potential wherein a number of protozoans subvert macrophage task. What emerges is an image of the macrophage as a key telephone style within the host reaction to protozoan an infection. How those cells reply, and the way their responses might be subverted, usually are serious determinants within the consequence of protozoan an infection. thousands of lives are misplaced each year to protozoan infections, most significantly these because of Plasmodium, but in addition Trypanosoma and Leishmania spp. different protozoans, corresponding to Toxoplasma, are so exquisitely tailored to their host that they hardly ever reason sickness, other than in the course of host immunodeficiency. we are hoping that via training an knowing of the biology of protozoans in macrophages we'll finally be ready to treating and fighting disorder and mortality brought on by this significant type of microbial pathogens.

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J Immunol 1997; 159:4452-4459. 12. Petersen E, Dubey JP. Biology of toxoplasmosis. In: Joynson DH, Wreghitt TJ, eds. Toxoplasmosis: A comprehensive Clinical Guide. Cambridge: University Press, 2001:1-42. 13. King CA. Cell motility of sporozoan protozoa. Parasitol Today 1988; 11:315-318. 14. Sibley LD. Invasion strategies of intracellular parasites. Science 2004; 304:248-253. 15. Håkansson S, Morisaki H, Heuser JE et al. Time-lapse video microscopy of gliding motility in Toxoplasma gondii reveals a novel, biphasic mechanism of cell locomotion.

Consistent with this porous vacuole, the genome sequence of T. org). Sequestered within the nonfusigenic vacuole, T. gondii is protected from access to both endogenous and exogenous antigen presentation pathways. 8,9 Even a low level of parasite death and digestion might suffice to prime both pathways for presentation. A more intriguing possibility is that select antigens gain access to the cytosol to induce presentation by the class I pathway. The demonstration that many components of rhoptries are injected into the cell during invasion47 provides one possible route for this.

Trends Microbiol 2003; 11:426-430. 18. Arrowood MJ, Sterling CR, Healey MC. Immunofluorescent microscopical visualization of trails left by gliding Cryptosporidium parvum sporozoites. J Parasitol 1991; 77:315-317. 19. King CA. Cell surface interaction of the protozoan Gregarina with Concanavalin A beads - Implications for models of gregarine gliding. Cell Biol Intl Rep 1981; 5:297-305. 20. Clark DP, Sears CL. The pathogenesis of cryptosporidiosis. Parasitol Today 1996; 12:221-225. 21. Wetzel DM, Schmidt J, Kuhlenschmidt M et al.

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