By Wolfgang Gaebel, Mario Maj, Norman Sartorius, Juan José López-Ibor Jr.
Psychiatry as a Neuroscience presents an summary of contemporary stable advances in organic psychiatry that are of scientific relevance.
* psychoneuroendocrinological and psychoimmunological findings in significant melancholy
* genetic and neuroimaging info in schizophrenia
* molecular genetic findings in Alzheimer's affliction
* neuroimaging info in obsessive-compulsive sickness.
This booklet could be of curiosity to psychiatrists and psychologists, neuroscientists, managers and coverage makers.
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Extra info for Psychiatry as a Neuroscience
479±493, Oxford University Press, New York. I. (1971) Man, Mind and Heredity: Selected Papers of Eliot Slater on Psychiatry and Genetics, Johns Hopkins Press, Baltimore. L. (1966) Psychiatric disorders in foster home reared children of schizophrenic mothers. Br. J. Psychiatry, 112: 819±825. S. (1983) Mental illness in the biological and adoptive relatives of schizophrenic adoptees, findings relevant to genetic and environmental factors in etiology. Am. J. Psychiatry, 140: 720±727. J. (1984) DNA in medicine.
The number of proteins is estimated to be ten times as high, about 300 000, since a gene can encode for multiple proteins by its subsequent ``tailoring'' and processing. Combinatorial chemistry has increased the pool of compounds that can be generated and tested against a specific protein target, and rational drug design based on structural imaging and modelling of proteins speeds up the drug discovery process by providing specific key-in-lock parameters for lead compounds. Further on the horizon, neuronal stem cells may lead to transplant approaches for those mental disorders where cell loss is involved, as is currently attempted in neurology for Parkinson's disease, for example.
Am. J. Psychiatry, 140: 720±727. J. (1984) DNA in medicine. Implications for medical practice and human biology. Lancet, 2: 1440±1444. , Plomin R. (2001) Toward behavioral genomics. Science, 291: 1232±1233. , Beyreuther K. (2000) Genetic basis of resistance to Alzheimer's disease and related neurodegenerative diseases. In Genes and Resistance to Disease (Eds V. Boulyjenkov, K. Berg, Y. Chrisen), pp. 121±131, Foundation IPSEN, Paris. 24 PSYCHIATRY AS A NEUROSCIENCE 10. J. (2001) Genetic risk of Alzheimer's disease: advising relatives.