By William I. Gay, James E. Heavner
Tools of Animal Experimentation, quantity VII: examine surgical procedure and Care of the examine Animal, half A is a set of papers that bargains with equipment utilized in animal experiments regarding sufferer care, vascular entry, and telemetry. This ebook issues applied sciences in experimental surgical procedure — complex methods requiring longer commentary time of the try out animal, and a rise within the spectrum of animals that may be used. One paper describes the anesthesia, analgesia, and types of restraints which are suited to the try animal. a wide range of selections of inhalational brokers, injectable, neighborhood anesthesia (lidocaine), analgesics (opioids and aspirin), and reticence (nonanesthesia and neuromuscular-blocking brokers) is offered for the researcher to choose between. numerous authors additionally describe using telemetry units which are implantable in try out animals to accomplish minimum interference from the investigator. those units contain sensors similar to circulate transducers and probes to exploit in pulse or non-stop wave-applications; electromagnetic flowmeters for blood tracking; and built-in circuits for numerous functions. One paper discusses postoperative care together with a sufferer care list, therapy of universal postoperative issues, in addition to venous catheters for fluid management. this article will be liked by way of veterinarians, technicians facing laboratory animals, and researchers designing animal and clinical experiments.
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Additional info for Research Surgery and Care of the Research Animal. Patient Care, Vascular Access, and Telemetry
4. Ultrasonic flow transducers with samples of the various size transducer cuff assemblies that can be used. The correct sized cuff can be chosen at the time of surgery, and the transducers will snap into the cuff. The center cuff shows one transducer already snapped into place. FIG. 5. Photograph of a ultrasonic flow transducer and cuff placed around the aorta of a dog. The transducer cables trail off to the right to a telemetry flowmeter. 44 JAMES D . MEINDL ET A L . perature, to a few thousand dollars for a more complex system, able to measure several channels of pressure, flow, or biopotentials.
As demonstrated by this study, long-term experimentation with primates is one type of research for which implantable biotelemetry is ideally suited. 7. Cardiotoxicity Research This final study developed a general animal model for examining the cardiovascular effects of various compounds. Most recently, this model was used to investigate the hemodynamic effects of doxorubicin (Andriamycin), a valuable anticancer drug that causes both acute cardiovascular effects and a dose-limiting cardiomyopathy (Jensen et ai, 1982, 1980).
9. 10. Harvard Biosciences 3900 Birch Street Commerce Park Newport Beach, California 92660 Bristol Laboratories Syracuse, New York 13201 Haver Lockhart Laboratories Shawnee Mission, Kansas 66202 Abbott Hospitals, Inc. North Chicago, Illinois 60064 Ayerst Laboratories, Inc. New York, New York 10017 Halocarbon Laboratories, Inc. 82 Builews Court Hackensack, New Jersey 07601 North American Drager 148 B. ) Schedule I. , heroin, LSD. Schedule II. , morphine, meperidine, pentobarbital. Schedule III. , nalorphine, thiamylal, thiopental.