By Manzoor A. Mir
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A smaller number of trials have investigated cortical models of stroke, with mixed results . Cortical strokes are associated with larger, more damaging infarcts, and it may be that these are too large to affect any repair. A direct comparison between subcortical and cortical infarcts in addition to various doses of cells would be useful in order to optimize patient selection. For example, one preclinical study that compared anatomical location found the benefit of stem cell therapy to be more pronounced in striatal infarcts, rather than larger cortical lesions .
Escudero Augusto, DL; Marqués Alvarez, F. Taboada Costa, Update in spontaneous cerebral hemorrhage, Med. Intensiva, 2008, 32, 282–295. Stary, HC. Macrophages, macrophage foam cells, and eccentric intimal thickening in the coronary arteries of young children, Atherosclerosis, 1987, 64, 91–108. Ip, JH; Fuster, V; Badimon, L; et al. Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation, J. Am. Coll. , 1990, 15, 1667–1687. An Introduction to Cerebrovascular Diseases 31  Ross, R.